Research on Anti-inflammatory Targets and Mechanisms of alkaloids in Picrasma quassioides Benn Through Network Pharmacology

Abstract This study aimed to investigate the molecular mechanism of Picrasma quassioides Benn against inflammation by means of network pharmacology. The paper will provide a reference for multi-target and multi-channel treatment of inflammation with traditional Chinese medicine. Through screening and analysis, 11 active ingredients and 109 anti-inflammation prediction targets were obtained and constructed a compound-target network. The targets such as VEGFA, TLR4 and STAT3 may play a crucial role. Network enrichment analysis showed that the 109 potential targets constitute a number of pathways or inflammatory reactions closely related to inflammation, including NF-κB signaling pathway and MAPK signaling pathway. The docking results indicated that the binding energy of Picrasidine Y and the inflammatory factors VEGFA is the highest. This study predicted the role of multiple active compounds in the alkaloids of Picrasma in the inflammatory response, and provided a theoretical basis for the anti-inflammatory mechanism of Picrasma

In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi

Abstract Existing medications i.e. the antipsychotic drugs are known to be effective in treating only the positive symptoms of schizophrenia, while being ineffective on negative and cognitive symptoms of the disease. In addition, these medications cause extrapyramidal symptoms, forcing many patients towards natural medicine in the hope of minimizing the unwanted adverse effects. Nardostachys jatamansi is a medicinal plant that has been traditionally prescribed for various types of brain disorders. The active constituents of the plant have beneficial effects on the negative and cognitive symptoms of schizophrenia. This study was designed to identify the active constituents of Nardostachys jatamansi with the highest binding affinities for the key macromolecular drug targets involved in the pathophysiology of schizophrenia and thereby elucidate the possible mechanism of action. These targets are dopamine receptors, Gamma-aminobutyric acid receptors, N-methyl-D-aspartate receptors and Phosphodiesterase 10A. The results of molecular docking showed that, β-sitosterol, chlorogenic acid, oleanic acid and ursolic acid, displayed high binding affinity toward all the macromolecular drug targets. Ligands with steroid backbone and pentacyclic triterpene structure have been found to possess high binding affinity toward the dopamine receptor and phosphodiesterase 10A. While ligands with carbonyl group form stronger binding interactions with the N-methyl-D-aspartate receptor.

The ancient Tuberculosis in the novel COVID-19 scenario

Abstract Recently, the world has coped with the challenge of the novel SARS-CoV-2 rapid spreading, causing COVID-19. This scenario has overburdened health systems, forced social isolation, and interrupted some services, changing the way how health assistance is provided. The management of chronic infectious diseases such as tuberculosis is a sensitive matter in times when the control strategies are at risk. In this sense, how could a high burden disease such as tuberculosis affect or be affected when combined with the COVID-19 pandemic? Patients with tuberculosis have a social background and lung impairment that represent risks in the pandemic scenario of another widely transmitted respiratory disease. Thus, even with several questions remaining unanswered, research and public policies should be addressed to control the effects of the current highly contagious COVID-19 without forgetting how it will affect the natural progression of patients suffering from tuberculosis.

Research on Molecular Mechanism of Fructus Ligustri Lucidi against Osteoporosis based on Network Pharmacology

Abstract TCMSP platform of systematic pharmacology of traditional Chinese medicine This study aimed to investigate the molecular mechanism of Fructus Ligustri Lucidi (NZZ, Chinese abbreviation) against osteoporosis (OP) by means of network pharmacology.ChemDraw Professional 15.1 software and Molinspiration Smiles database were used to draw the chemical formulas of the components. The active ingredients and related target proteins of NZZ were searched in platform of systematic pharmacology of traditional Chinese medicine database, Drugbank, Therapeutic Target Database, SymMap and other databases. Gene Ontology(GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were carried out on the selected target through Enrichr and KEGG Automatic Annotation databases, and their mechanism was studied. A total of 29 compounds and 140 corresponding targets, including 14 key targets and 14 protein factors in protein-protein interaction core network were obtained. The key targets were tumor necrosis factor(TNF), interleukin(IL)-6R and sestrogen receptor alpha. The number of GO items was 466 (P<0.05), including 399 items of biological process (BP), 54 items of cell composition (MF) and 13 items of molecular function (CC). KEGG pathway enrichment screened 85 signaling pathways (P<0.05), including the IL-17 signaling pathway, TNF signaling pathway, advanced glycation end products and their receptors signaling pathway and cAMP signaling pathway. The active ingredients of NZZ. exert their anti-OP effects through multi-components, multi-targets and multi-pathways, which can provide new evidence for further study of their anti-OP mechanism.

Aportes al debate sobre investigación teórica o conceptual / Contributions to the debate on theoretical or conceptual research

El presente artículo pretende abonar el debate sobre la delimitación y alcance de lo que en algunos informes de investigación y en la bibliografía existente se ha nominado como investigación teórica o investigación conceptual. Aunque varios autores hacen referencia a este tipo de investigaciones hemos encontrado ambigüedades en el uso de estos términos, así como inespecificidades o superposiciones en estas nominaciones y en las connotaciones y clasificaciones que les subyacen. Algunas de las divergencias relevadas son las que tienden a confundir la investigación conceptual con la investigación cualitativa, la investigación bibliográfica o documental, el estudio de caso, las monografías o incluso lejos de encuadrarse en un cierto tipo de investigación, hacer extensiva la confusión a conceptos metodológicos tales como marco teórico o rastreo del estado del arte. Proponemos revisar los fundamentos, implicancias y alcances específicos de este tipo particular de investigaciones a partir de algunas reflexiones epistemológicas y metodológicas(AU)

This article aims to support the debate on the delimitation and scope of what in some research reports and in the existing bibliography has been nominated as theoretical research or conceptual research. Although several authors refer to this type of research, we have found ambiguities in the use of these terms, as well as non-specificities or overlaps in these nominations and in the connotations and classifications that underlie them. Some of the divergences found are those that tend to confuse conceptual research with qualitative research, bibliographic or documentary research, case studies, monographs or even far from being framed in a certain type of research, extending the confusion to concepts methodologies suchas theoretical framework or tracking of the state of the art. We propose to review the foundations, implications and specific scope of this particular type of research based on some epistemological and methodological reflections(AU)

Cet article vise à soutenir le débat sur la délimitation et la portée de ce qui dans certains rapports de recherche et dans la bibliographie existante a été nommé comme recherche théorique ou recherche conceptuelle. Bien que plusieurs auteurs se réfèrent à ce type de recherche, nous avons trouvé des ambiguïtés dans l'utilisation de ces termes, ainsi que des non-spécificités ou des chevauchements dans ces nominations et dans les connotations et classifications qui les sous-tendent. Certaines des divergences constatées sont celles qui tendent à confondre la recherche conceptuelle avec la recherche qualitative, la recherche bibliographique ou documentaire, les études de cas, les monographies ou même loin de s'inscrire dans un certain type de recherche, étendant la confusion aux concepts méthodologiques tels que cadre théorique ou suivi de l'état de l'art.Nous proposons de passer en revue les fondements, les implications et la portée spécifique de ce type particulier de recherche à partir de quelques réflexions épistémologiques et méthodologiques(AU)

Este artigo tem como objetivo apoiar o debate sobre a delimitação e o alcance do que em alguns relatórios de pesquisa e na bibliografia existente tem sido denominado como pesquisa teórica ou pesquisa conceitual. Embora vários autores façam referência a esse tipo de pesquisa, encontramos ambigüidades no uso desses termos, bem como não especificidades ou sobreposições nessas nomeações e nas conotações e classificações que as fundamentam. Algumas das divergências encontradas são aquelas que tendem a confundir pesquisa conceitual com pesquisa qualitativa, pesquisa bibliográfica ou documental, estudos de caso, monografias ou mesmo longe de estarem enquadradas em um determinado tipo depesquisa, estendendo a confusão a conceitos metodológicos como referencial teórico ou acompanhamento do estado da arte.Propomo-nos a fazer uma revisão dos fundamentos, implicações e alcance específico deste tipo particular de investigação a partir de algumas reflexões epistemológicas e metodológicas(AU)

Quinolinotriazole antiplasmodials via click chemistry: synthesis and in vitro studies of 7-Chloroquinoline-based compounds

Malaria is nowadays one of the most serious health concerns in a global scale and, although there is an evident increase in research studies in this area, pointed by the vast number of hits and leads, it still appears as a recurrent topic every year due to the drug resistance shown by the parasite exposing the urgent need to develop new antimalarial medications. In this work, 38 molecules were synthesized via copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) or "click" chemistry, following different routes to produce 2 different organic azides, obtained from a 4,7 dicholoquinoline, reacted with 19 different commercially available terminal alkynes. All those new compounds were evaluated for their in vitro activity against the chloroquine resistant malaria parasite Plasmodium falciparum (W2). The cytotoxicity evaluation was accomplished using Hep G2 cells and SI index was calculated for every molecule. Some of the quinoline derivatives have shown high antimalarial activity, with IC50 values in the range of 1.72-8.66 µM, low cytotoxicity, with CC50>1000 µM and selectivity index (SI) in the range of 20-100, with some compounds showing SI>800. Therefore, the quinolinotriazole hybrids could be considered a very important step on the development of new antimalarial drugs

Investigaciones clínicas sobre Medicina Natural y Tradicional publicadas en revistas cubanas / Clinical researches on natural and traditional medicine published in Cuban journals

RESUMEN Introducción: los profesionales dedicados a la medicina natural y tradicional deben establecer y divulgar las evidencias científicas para su uso adecuado y seguro. Objetivos: identificar artículos científicos relacionados con investigaciones clínicas sobre medicina natural y tradicional en revistas médicas cubanas y describir algunas de sus características. Material y Método: estudio descriptivo, transversal; se analizaron los artículos originales publicados entre los años 2007 y 2018 en seis revistas médicas cubanas: Plantas Medicinales, Medicina Natural y Tradicional, Medicina General Integral, Estomatología, Medicina Militar y Farmacia; realizados en personas y en Cuba. Se identificó año de publicación, tipo de estudio (descriptivo, analítico, ensayo clínico), variable principal (eficacia, seguridad, otros), provincia dónde se ejecutó; en los ensayos clínicos se identificó la modalidad empleada, la enfermedad del paciente y el nivel de atención de salud en que se realizaron. Resultados: se encontraron 36 artículos; se publicaron más en los años 2007 y 2016; 69,4 % eran ensayos clínicos; la mayoría se realizó en La Habana (41,6%). En los ensayos clínicos las modalidades más estudiadas fueron la acupuntura (28,0 %) y la fitoterapia, 20,0%; se emplearon más en pacientes con enfermedades estomatológicas, 28,0%; su ejecución predominó en el nivel primario de atención de salud, 64,0%. Conclusiones: fueron insuficientes los artículos relacionados con investigaciones clínicas sobre medicina natural y tradicional que se publicaron en seis revistas que abordan esta temática, esta situación atenta contra la prescripción de esta opción terapéutica, basada en evidencias científicas (AU).

SUMMARY Introduction: the professionals devoted to natural and traditional medicine should study and publish the scientific evidences for its rational and safe use. Objectives: to identify scientific articles related to clinical researches on natural and traditional medicine in Cuban medical journals and to describe some of their characteristics. Materials and methods: a cross-sectional descriptive study; the authors analyzed the original articles published in the period 2007-2018 on researches made in Cuban people and in Cuba in six Cuban medical journals: Plantas Medicinales, Medicina Natural y Tradicional, Medicina General Integral, Estomatología, Medicina Militar y Farmacia. The year of publication, kind of study (descriptive, analytic, clinical trial), main variable (efficacy, safeness, others), and province where they were identified; in the case of clinical trial: the used modality, the patient's disease and the level of the health care where they took place were also identified. Results: 36 articles were found; the years when they were published the most were 2007 and 2016; 69.4 % were clinical trials; most of them were carried out in La Habana (41.6 %). In clinical trials, the most studied modalities were acupuncture (28.0 %) and physiotherapy (20.0 %); they were used more in patients with dental diseases (28.0 %); they were used mainly at the primary health care (64.0 %). Conclusions: there were insufficient the articles related to clinical researches on natural and traditional medicine published in six journals approaching these themes; this situation attempts against the use of this therapeutic use, based on scientific evidences (AU).

Paulo Freire's research itinerary: contributions for promoting health in the teaching profession / Itinerario de Investigación de Paulo Freire: contribuciones a la promoción de salud en el trabajo docente / Itinerário de Pesquisa de Paulo Freire: contribuições para Promover a Saúde no Trabalho Docente

ABSTRACT Objectives: examine Paulo Freire's research itinerary as a theoretical-methodological framework and its contributions for promoting health in the teaching profession. Methods: qualitative participatory action research coordinated with Paulo Freire's itinerary, carried out in culture circles, from April 18, 2018 to June 26, 2018. It involved the participation of 21 teachers from a federal teaching institution. Results: the method that was used promoted dialogue and reflection among the participants, enabling a health promotion intervention. It facilitated self-knowledge and reflection, resulting in significant changes in the participants, in a process in pursuit that seeks transformations. Final Considerations: Paulo Freire's research itinerary was opportune, as a possibility for promoting health, mainly in terms of providing a framework that assists in the practical construction of knowledge and encourages participants to examine their reality in the pursuit of enhanced quality of life.

RESUMEN Objetivos: analizar el Itinerario de Investigación de Paulo Freire como referencial teórico metodológico y sus contribuciones a la promoción de salud en el trabajo docente. Métodos: estudio cualitativo tipo acción participante, articulada al Itinerario de Investigación de Paulo Freire, desarrollada en cinco círculos culturales, entre el 18/04/2018 y el 26/06/2018. Participaron 21 profesores de una institución educativa federal. Resultados: el método utilizado contribuyó al diálogo y la reflexión entre los participantes, posibilitando una intervención de promoción de salud. Facilitó el autoconocimiento y la reflexión, provocando cambios significativos en los participantes hacia un proceso de búsqueda de transformaciones. Consideraciones Finales: el Itinerario de Investigación de Paulo Freire resultó conveniente. Se lo considera oportuno para la promoción de salud, particularmente por tratarse de un referencial que favoreció la construcción práctica de saberes y por promover que los participantes analizaran su realidad en la búsqueda de calidad de vida.

RESUMO Objetivos: analisar o Itinerário de Pesquisa de Paulo Freire como referencial teórico metodológico e contribuição para Promover Saúde no Trabalho Docente. Métodos: pesquisa qualitativa do tipo ação participante articulada ao Itinerário de Paulo Freire, desenvolvida em cinco Círculos de Cultura, no período de 18/04/2018 a 26/06/2018. Envolveu a participação de 21 professores deem uma instituição de ensino federal. Resultados: o método utilizado contribuiu para diálogo e reflexão entre os participantes e permitiu uma intervenção para a promoção da saúde. Cooperou para autoconhecimento e reflexão, proporcionando mudanças significativas dos participantes, para um processo de busca por transformações. Considerações Finais: o Itinerário de Pesquisa de Paulo Freire apresentou-se oportuno. É percebido como uma possibilidade para promover a saúde, principalmente quando se trata de um referencial que ajudou na construção prática de saberes e estimulou os participantes a analisarem sua realidade na busca de qualidade de vida.

A segurança do paciente nos caminhos percorridos pela enfermagem brasileira / Seguridad del paciente en los caminos transitados por la enfermería brasileña / Patient safety in nursing paths in Brazil

RESUMO Objetivo: sumarizar as dissertações e teses produzidas por enfermeiros disponíveis no Catálogo de Teses e Dissertações da Associação Brasileira de Enfermagem, do volume XIX ao XXXII, que abordam a segurança do paciente. Método: pesquisa documental. Após coleta de dados, analisaram-se as seguintes variáveis: nível acadêmico, instituição de ensino, ano, local, tipo de serviço, objeto de estudo, desenho metodológico, sujeitos, protocolo prioritário de segurança do paciente, implicações e recomendações finais. Resultados: encontrados 8.720 resumos, dos quais 53 (0,61%) foram analisados. Houve predomínio de dissertações (n=19; 35,85%) relacionadas à redução do risco de quedas e úlcera por pressão (n=24; 45,28%), do tipo descritivo (n=21; 39,62%), quantitativo (n=16; 30,19%), no cenário hospitalar (n=16; 30,19%), utilizando escalas e protocolos (n=6; 11,32%). Conclusão: observou-se tendência para desenvolvimento de estudos relacionados à segurança do paciente no cenário hospitalar, com ênfase na redução do risco de úlcera por pressão.

RESUMEN Objetivo: sintetizar las disertaciones y tesis realizadas por enfermeros, disponibles en el Catálogo de Tesis y Disertaciones de la Asociación Brasileña de Enfermería, del volumen XIX al XXXII, abordando la seguridad del paciente. Método: investigación documental. Después de recolectar los datos, se analizaron las variables: nivel académico, institución de enseñanza, año, lugar, tipo de servicio, objeto de estudio, diseño metodológico, sujetos, protocolo primario de seguridad del paciente, implicaciones y recomendaciones finales. Resultados: se encontraron 8.720 resúmenes, de los que 53 (0,61%) fueron analizados. Predominaron disertaciones (n=24; 45,28%), de tipo descriptivo (n=21; 39,62%), cuantitativo (n=16; 30,19%), en ámbito hospitalario (n=16; 30,19%), utilizando escalas y protocolos (n=6; 11,32%). Conclusión: Se observó tendencia al desarrollo de estudios relacionados a la seguridad del paciente en ámbito hospitalario, con énfasis en la reducción del riesgo de úlcera por presión.

ABSTRACT Objective: summarize the dissertations and theses produced by nurses available in the Catalog of Theses and Dissertations of the Brazilian Nursing Association, from volume XIX to XXXII, that address patient safety. Method: this is a documentary study. After data collection, the following variables were analyzed: academic level, educational institutions, year, place, type of service, study object, study method, subjects, priority protocol of patient safety, implications and final recommendations. Results: 8,720 abstracts were found, 53 (0.61%) of which were analyzed. There was a predominance of dissertations (n=19; 35.85%) regarding the reduction of risks for fall and pressure ulcer (n=24; 45.28%), of descriptive type (n=21; 39.62%), quantitative type (n=16; 30.19%), in hospital environments (n=16; 30.19%), using scales and protocols (n=6; 11.32%). Conclusion: there is a tendency towards the development of studies related to patient safety in hospital environments, with an emphasis on the reduction of risk for pressure ulcer.

Investigación clínica en Guatemala / Clinical research in Guatemala

Los avances en diferentes aspectos en el diagnóstico, tratamiento y rehabilitación en el área médica, han avanzado a través de los años. En las últimas décadas estos progresos han ocurrido más rápidamente y se han basado en hechos que se comprueban y ratifican por medio de investigaciones conducidas en forma ética y dentro del marco de regulaciones internacionales y locales. Es importante mencionar que existen diversos tipos de investigación. La epidemiológica describe la distribución de enfermedades y eventos de salud en poblaciones humanas por medio de estrategias que permiten clasificar los estudios en observacionales y experimentales. Los observacionales se caracterizan por describir las enfermedades y el investigador es un espectador analista pasivo que no realiza ninguna intervención en los sujetos participantes. Pueden ser descriptivos o analíticos, como los estudios de casos-controles-cohortes, en los que se pueden identificar relaciones entre las variables estudiadas. En este artículo nos ocuparemos de los estudios experimentales, los que proporcionan el máximo grado de evidencia para establecer la relación de causa y efecto entre la exposición y el evento en estudio; es el mejor método para comparar eficacia y/o seguridad en intervenciones y tratamientos y se caracteriza por aplicar una intervención en los sujetos participantes similar a la aplicada a un grupo control...(AU)

Advances in different aspects of diagnosis, treatment and rehabilitation in the medical area have advanced over the years. In recent decades, these advances have occurred more rapidly and have been based on facts that are verified and ratified through research conducted ethically and within the framework of international and local regulations. It is important to mention that there are different types of research. The epidemiological study describes the distribution of diseases and health events in human populations through strategies that allow classifying studies in observational and experimental. The observational ones are characterized by describing the diseases and the researcher is a passive analyst spectator who does not perform any intervention on the participating subjects. They can be descriptive or analytical, such as case-control-cohort studies, in which relationships between the variables studied can be identified. In this article we will deal with experimental studies, which provide the maximum degree of evidence to establish the cause and effect relationship between the exhibition and the event under study; it is the best method to compare efficacy and / or safety in interventions and treatments and is characterized by applying an intervention in the subjects similar to that applied to a control group ... (AU)

Usos teórico-metodológicos das pesquisas na área de Ciências Sociais e Humanas em Saúde / Theoretical and methodological uses of research in social and human sciences in health

O presente artigo visa a mapear os usos teórico-metodológicos correntes nas pesquisas do subcampo das Ciências Sociais e Humanas em Saúde, refletindo criticamente sobre eles. Foram selecionadas, por amostra de conveniência, três revistas brasileiras da área da saúde coletiva. Com base na leitura de 1.128 resumos publicados nos anos de 2009 e 2010, foram selecionados 266 artigos que apresentavam base empírica de investigação com aporte nos métodos oriundos das Ciências Sociais e Humanas em Saúde. O acervo composto foi classificado conforme as temáticas "referencial teórico-metodológico", "tipo de estudo-desenho metodológico", "categorias analíticas utilizadas", "técnicas para a produção de dados" e "procedimentos de análise". Analisamos as categorias êmicas do acervo, valendo-nos das declarações literais dos autores. Todas as classificações e respectivas variáveis foram tabuladas em Excel. A maior parte dos artigos se autodenominou qualitativa e utilizou mais de uma técnica para a produção dos dados. Observou-se grande variedade de referenciais teóricos em contraste com a quase total predominância de um único tipo de análise de dados (análise de conteúdo). Em vários casos, identificaram-se lacunas importantes na exposição da metodologia da pesquisa e utilização instrumental das técnicas e métodos de pesquisa qualitativos. Destacam-se, porém, novos objetos de estudo e inovações teórico-metodológicas.

The current article aims to map and critically reflect on the current theoretical and methodological uses of research in the subfield of social and human sciences in health. A convenience sample was used to select three Brazilian public health journals. Based on a reading of 1,128 abstracts published from 2009 to 2010, 266 articles were selected that presented the empirical base of research stemming from social and human sciences in health. The sample was classified thematically as "theoretical/ methodological reference", "study type/ methodological design", "analytical categories", "data production techniques", and "analytical procedures". We analyze the sample's emic categories, drawing on the authors' literal statements. All the classifications and respective variables were tabulated in Excel. Most of the articles were self-described as qualitative and used more than one data production technique. There was a wide variety of theoretical references, in contrast with the almost total predominance of a single type of data analysis (content analysis). In several cases, important gaps were identified in expounding the study methodology and instrumental use of the qualitative research techniques and methods. However, the review did highlight some new objects of study and innovations in theoretical and methodological approaches.

Análise das pesquisas de Iniciação Científica da Fonoaudiologia da PUC-SP: resgatar o passado para melhor planejar o futuro / Analysis of Research Scientific Initiation of Speech Therapy at PUC-SP: recovering the past to better plan the future

O objetivo foi analisar as pesquisas de iniciação científica, desenvolvidas ou em desenvolvimento, no Curso de Fonoaudiologia da PUC-SP, no período compreendido entre 2000 a 2008. O levantamento contou com o auxílio da secretaria da Faculdade de Fonoaudiologia, que arquiva todos os dados referentes às mesmas. Os dados dos resumos foram registrados em planilha considerando: título da pesquisa; ano; temática; faixa etária dos sujeitos envolvidos; tipo de atuação fonoaudiológica; local da ação fonoaudiológica; órgão financiador da pesquisa e número de alunos envolvidos na pesquisa. Foram encontradas 131 iniciações científicas. Desse total, o ano de 2003 registrou maior número de trabalhos desenvolvidos (19,8%); a audição foi temática pesquisada em metade das pesquisas (50,4%); e a faixa etária, que compreende a infância e a adolescência, foi a mais estudada (27,5%). Com relação ao tipo de atuação fonoaudiológica, em torno da metade preocupou-se com avaliação/diagnóstico (54,2%), e quanto ao local a clínica/instituição foi a priorizada (19,8%). Os bolsistas, geralmente em dupla (56,5%) foram financiados pela Comissão de Ensino e Pesquisa da PUC-SP (49,6%) e pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (50,4%). A pesquisa demonstrou o crescimento das produções científicas e a necessidade de melhor distribuição quanto às temáticas, à faixa etária e ao tipo de atuação fonoaudiológica investigada.

The aim of this study was to analyze the scientific initiation researches developed or in development, in the Speech Language Pathology college at PUC-SP, comprehending the period between 2000 and 2008. The data collection was carried out at the secretary of the Speech Therapy college and recorded in spreadsheets considering: research title; year; theme; professional practice; local; funding institution; the number of students involved in the research; and publication. 131scientific initiation projects were considered. From this total, the year with most studies being presented was 2003 with 19.8% of the total; as far as the themes being researched, audiology represented 50.4% of the projects; in regards to the studied age group, 27.5% was performed with children and adolescents. In the field of speech therapy practice, 54.2% studied evaluation/diagnosis; in 47.3% there were no established research settings. The scholarship holders, generally in pairs (56.5%) opted similarly among the two types of available funding (CEPE -49,6%; CNPq - 50,4%). The research showed a growth in scientific outputs. However, it is important to obtain a better distribution of studied themes, age groups and types of practice. It is believed that the presented data will aid in the development of researches that aim to analyze the Speech Language Pathology scientific output.

Esta investigación tuvo el propósito a analizar las investigaciones de la iniciación científica, desarrollado o en el desarrollo, en el Curso de Fonoaudiología del PUC-SP, comprendiendo el período entre 2000 y 2008. La recogida de datos fue llevada a cabo en el secretario de la facultad de la Fonoaudiología y registro en planilla considerando: el título de investigación; año; el tema; actuación; local; patrocinador; el número de estudiantes involucrados en la investigación. Fue considerado 131 iniciaciones científicas. De este suma, el año que presentó más trabajo fue 2003 con 19,8%; acerca de los temas investigó la audiología tuvo 50,4%; por el grupo de edad, 27,5% con niños y adolescentes. En la actuación fonoaudiologica, 54,2% estuvo en el evaluación/diagnóstico; en 47,3% no fue establecido los lugares de investigación. Los becarios, generalmente en par (56.5%) hace la opción por el patrocinador de forma semejante (CEPE - 49,6%; CNPq - 50,4%). De los trabajos realizados 14,51% fueron publicados. La investigación mostró el crecimiento de las producciones científicas, sin embargo es importante que una mejor distribución considere los temas, la distribución por edad y los tipos de actuación. Es creído que estos datos podrán ayudar el desarrollo de investigaciones que analizarán la producción científica de la Fonoaudiología.